So, I recently finished A Canticle for Leibowitz. I can't believe it took me this long to read it (30-some years? When did you first recommend it, Jack?) Beautiful, horrible, gut-wrenching, and thought-provoking, it delves into the connections among faith, reason, knowledge, science/technology, church, state, and man's ever-predictable penchant for overreaching and destroying himself.
"Ask for an omen, then stone it when it comes -- de essentia hominum."
Do you want to discuss? We'll start it in the comments, so as to prevent spoilers, of course.
(I've got a busy couple of days coming up, so if I don't get a chance to jump right in, please be patient with me...I will get back to the discussion!)